求nature全文：http://www.nature.com/nrm/journal/v12/n4/full/nrm3086.html
答案:1 悬赏:40
解决时间 2021-04-28 09:40
- 提问者网友：萌萌小主
- 2021-04-27 16:33
敝人现不在学校，无法弄到这篇nature上的文献
最佳答案
- 二级知识专家网友：蜜罐小熊
- 2021-04-27 17:33
The p53 family: guardians of maternal reproduction
Arnold J. Levine, Richard Tomasini, Frank D. McKeon, Tak W. Mak & Gerry Melino
Abstract
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.
Arnold J. Levine, Richard Tomasini, Frank D. McKeon, Tak W. Mak & Gerry Melino
Abstract
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.
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